Winry retains her same appearance as she does in anime, she wears her casual Black Jacket and is always carrying around her suitcase when she travels.
Winry's Personality remains unchanged from the anime and Manga, being both occasional comic relief and being emotional support for the Elric Brothers, fixing them up any time they need to be. She is also still obsessive over automail .
Undoubtedly the most significant of her relationships; as such, however, Edward argues with Winry even more than he does with Al, their similarly stubborn personalities keeping them at odds with one another despite their powerful bond. After the terrible accident that claimed Ed's right arm and left leg, Winry took on the role of his personal automail mechanic, building him sophisticated new limbs at the tender age of eleven. Since then, Winry has served as Ed's constant well of support, both mechanically and emotionally, though they still find themselves arguing frequently. However, this affectionate hostility appears to be masking a deeper relationship. Though Edward has not outwardly admitted any romantic feelings toward Winry, he is rather overprotective of her and becomes unnaturally flustered at the mere suggestion of an amatory relationship between them. Winry, for her part, has admitted to herself that she had been falling for him all along. They finally confess to each other at the end of the series as Edward proposes to her, although they use The Law of Equivalent Exchange to do so. According to the Fullmetal Alchemist Chronicle (Official Guide), they got married in 1917 and had many children in the end.
Alphonse appears to be the little brother Winry always wanted. While Al remarks on the fight both he and Edward had over which one of them would marry her, Winry doesn't appear to have regarded those feelings as being too deep, as she is very casual about how she turned down both brothers' affections at the time. However, Winry does seem to be the one person other than Edward who is most affected by Al's intangible state as a soul bound to a suit of armor. She also seems to unquestioningly regard Al as human, despite the doubts others sometimes express about that. She is both protective and defensive of Al's humanity, and cries openly for his pain as well.
Even since before the death of her parents during the Ishval Civil War, Winry has always had a close relationship with her grandmother, but since the tragedy that befell the Rockbell homestead, Pinako has served as Winry's sole caretaker and closest - if not only - blood relation. The two have a relatively amicable relationship, ribbing each other every so often as they go about their days jointly running their automail atelier, but the bond between them remains as that of doting grandparent and an adoring grandchild. When Winry finally sets out on her own path as an automail engineer, Pinako worries silently that the greater world will be too hard on her little Winry, but is very proud when she sees and hears evidence of the young woman's progress. Conversely, Winry worries about leaving her grandmother alone and communicates with her regularly, knowing that there will always be a place for her at home in Resembool if she should so require.
Encountering Lt. Colonel Maes Hughes almost by chance during her first trip to Central City, Winry is immediately accepted into Maes' circle of friends as he practically drags her to his daughter Elicia Hughes's third birthday party. She becomes close to little Elicia, who quickly comes to regard Winry as an older sister, as well as Maes' wife Gracia Hughes, who periodically offers the teenage girl motherly advice while teaching her to bake. After Maes's death, Winry remains close to Gracia and Elicia, sustaining an almost familial bond.