As mutant beasts granted the traits of multiple species, standard chimera appear best suited for guard duty and are frequently positioned as such; in the manga, Father keeps an innumerable horde of these fantastic beasts guarding the underground passageways to his lair and, in the 2003 anime series, the State Military contains a great number of reptilian feline chimera in Laboratory 5 tasked with eliminating intruders that manage to elude Guards Number 48 and Number 66. Later in the 2003 anime, Shou Tucker created new chimera for Frank Archer and some of them were placed under the command of Solf J. Kimblee during the mission to stir up tensions in Reole.
While the synthesis of the chimera is an accepted, albeit rare and elusive branch of alchemy, the concept of extending its mutative hand to the realm of human characteristics and abilities falls under Human Transmutation and is therefore strictly banned as a practice under the authority of the military. On the other hand, though there are alchemists who flout this decree and step across the threshold into monstrous experimentation, it has been publicly stated that all illicit attempts to create a human-animal hybrid have failed. This is untrue.
State Alchemist Shou Tucker has been accredited with the creation of the first chimera capable of human speech, but it died soon after creation because it refused to eat, but the truth of the matter is that his creation was actually a crude human chimera created in secrecy and passed off as an advanced standard chimera to achieve his state certification. It was only during his second attempt at this that his transgressions were brought to the government's attention. However, the State Military itself has been experimenting with synthesizing human chimera in secret laboratories for some time, with limited success. The worst part of it is that Tucker used his wife and later, his daughter and dog to make the chimeras.
Human chimera similar to those created by Shou Tucker are marked as failures by the military, having very little social ability and significantly warped forms while experiencing high levels of physical pain due to having internal systems that are incomplete or otherwise insufficient for maintaining their new hybridized bodies; still, having been human at one point, their souls and memories remain largely intact, despite a limited ability to convey their feelings and thoughts to other humans. A step above these complete failures are the chimera that maintain much of their original human forms but with added physical traits that enhance their physical abilities while often making them incapable of blending in with society as normal human beings.
Human chimera that are deemed "successes" by the State Military belong to two categories as well. There are those with entirely human outward forms whose internal makeups have incorporated increased senses, versatile physical structures, and abilities identical to the animals with which they have been alchemically spliced, granting them superhuman traits while maintaining an inconspicuous shape. However, the form the military seems to have accepted as their ultimate success in regards to the creation of human chimera is that which is capable of transforming from full human form to that of a man-beast hybrid and back at will.
List of Human Chimera by Faction
- Mr. Shou Tucker's Chimera
- Greed's chimera
- Solf J. Kimblee's chimera (later allied with Ed and the "new" Greed)
- Ashleigh Crichton's chimera
- The Homunculus Sloth was once passed off as a chimera at work by Lt. General Raven as a cover story when they were both at Fort Briggs.
- One of the chimeras that protect Father was modeled after Cerberus, the three-headed dog that guarded the gates of the Ancient Greek underworld.
- Originally from Greek Mythology, a chimera is a monstrous fire-breathing fearsome beast bearing the heads of both a lion and a goat while its tail takes the form of a giant snake. Cornello´s chimera is the one who best fits this description.