Lust

(Japanese:ラスト, Rasuto) is a humuncolus with the ability of extend her fingernails or fingertips, to use them like blades in an attack known as the Ultimate Lance. She is one of the first homonculi to be revealed and is often seen with Gluttony.

In the anime
In the anime, Lust was created when Scar's brother tried to revive his dead lover. Though originally largely the same as her manga counterpart, Lust begins to crave becoming a human as the series progresses. This leads her to defecting from the homunculi and joining sides with Edward Elric under the condition that they help make her human. She is ultimately tracked down by Wrath who, after paralyzing her with a locket that contains strands of hair from her original body, kills her.

In the manga
In the manga, after leading an effort to capture Barry the Chopper, her plans backfire when Roy Mustang infiltrates into the homunculi's secret lair. Though she is able to severely wound him, he sears his wounds shut and kills her by repeatedly setting her on fire.