Alexander

Alexander was the family pet of the Tucker Family and Nina's closest best friend. His breed appears to be a Great Pyrenees. In the manga and both animes, Alexander and Nina grow very close to the Elric brothers, but their friendship was not able to last as Shou Tucker needed to present an astounding alchemic breakthrough to the military to make up for his past failures and avoid having his license revoked. Desperate, Tucker resorts to transmuting Alexander and Nina together to create a talking (yet imperfect) Chimera. When the Elric brothers discover this, Edward beats Shou to near death for having done such a cruel thing. With no idea on how to restore Nina and Alexander, the brothers leave the rest in the hands of the military, but the State Alchemist killer Scar soon arrives and kills Nina's father, and, noticing the pain the Nina/Alexander creature is in, kills it in an act of mercy.

Trivia

 * There is some speculation that Alexander is partially based on the character Mr. Tadakichi-san, the pet of Chiyo Mihama in the manga/anime series Azumanga Daioh. Both dogs appear to be Great Pyrenees, dogs typically of massive size, and both have the habit of letting their respective owners, young girls, ride on their backs. This is unconfirmed, as the date of the first appearance of Mr. Tadakichi is unknow, while Alexander first appeared in Chapter 5, released December 2001.