Flamel

The Flamel refers to the mystical and alchemical symbol depicted as a cross with a snake or serpent draped about it, a crown and wings above. Its origins may be traced back to such symbols as the Rod of Asclepius (the ancient Greek sign of medicine), the Caduceus (the ancient Greek sign of wealth) and/or the Serpent Cross (a sign signifying victory over the devil), but regardless of its true meaning, it is one of the symbols attributed to the ancient professed French alchemist, Nicolas Flamel.

In the Fullmetal Alchemist series, the Flamel symbol is the mark depicted on the back of Edward Elric's trademark red coat and on the left shoulder of Alphonse Elric's armor body. Though the manga does not explicitly state the true meaning of the mark, the Elrics' alchemy teacher, Izumi Curtis also bears the mark, tattooed on her left collarbone, implying that the brothers share their master's alchemic symbol to show their tutelage under her.

In the 2003 anime series, Izumi states that the mark is that of her alchemy teacher, Dante. Above Dante's wooden chair in the library in her house, there is a golden statue of this symbol. Also, the Transmutation Circle used to weaken Homunculi is centered around this design.